Picoelectrospray Ionization Mass Spectrometry Using Narrow-Bore Chemically Etched Emitters
نویسندگان
چکیده
منابع مشابه
Chemically etched open tubular and monolithic emitters for nanoelectrospray ionization mass spectrometry.
We have developed a new procedure for fabricating fused-silica emitters for electrospray ionization-mass spectrometry (ESI-MS) in which the end of a bare fused-silica capillary is immersed into aqueous hydrofluoric acid, and water is pumped through the capillary to prevent etching of the interior. Surface tension causes the etchant to climb the capillary exterior, and the etch rate in the resul...
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Electrospray ionization (ESI) has revolutionized mass spectrometry (MS), providing a facile method for the ionization of macromolecules for analysis by mass. The development of nanoESI-MS has further extended the utility of ESI-MS, permitting the analysis of small-volume samples with enhanced sensitivity over conventional ESI-MS. Traditional nanoESI-MS experiments use pulled-glass capillary emi...
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Common to all experiments in mass spectrometry is the creation of gas-phase ions. Electron impact (EI) ionization is a familiar method for creating ions from volatile gas-phase molecules (M). In EI ionization, fast-moving electrons remove an electron from the neutral molecule to create the odd-electron molecular ion M`Õ. Another common ionization method is chemical ionization (CI). Here, an ion...
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ژورنال
عنوان ژورنال: Journal of The American Society for Mass Spectrometry
سال: 2013
ISSN: 1044-0305,1879-1123
DOI: 10.1007/s13361-013-0749-z